Some Biological and Chemical Properties of a Lysine- Vasopressin Dimer.

نویسندگان

  • A V SCHALLY
  • R GUILLEMIN
چکیده

In the course of fractionation of neurohypophysial extracts in search for corticotropin-releasing factor (1) we sometimes observed materials with low pressor activity, consistent corticotropin-releasing activity, and with the same molar ratios of amino acids as lysine-vasopressin. In view of the report by Ressler on a possible dimerkation of oxytocin (2), it was decided to investigate these materials with the hypothesis that their peculiar biological properties may be due to polymerization of vasopressin.

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عنوان ژورنال:
  • The Journal of biological chemistry

دوره 239  شماره 

صفحات  -

تاریخ انتشار 1964